Lost Highway has been described by its director as a 21st century film noir, a graphic investigation into parallel identity crises, a world where time is dangerously out of control and finally a terrifying ride down the lost highway. With typically Lynchian dreamlike quality, Lost Highway expands the horizons of the medium, taking its audience on a journey through the unknown and the unknowable. It is not only about the human psyche, it seems to take place inside it.

Set in a city of Lynch's imagination, Lost Highway focuses on two separate but intersecting stories. One about musician Fred Madison (Bill Pullman), tortured by the notion that his wife Renee (Patricia Arquette) is having an affair, who suddenly finds himself accused of her murder. The other concerns a young mechanic (Balthazar Getty) drawn into a web of deceit by a temptress who is cheating on her gangster boyfriend (Robert Loggia). The tales are connected by a mind-blowing turn of events that calls into question the protagonists' very identities. It all makes for a classic Lynchian nightmare.